History

 

PottersWheel originates from the Ph.D. thesis of Dr. Thomas Maiwald at the University of Freiburg in the group of Prof. Jens Timmer. The implemented concepts have been published in

Dynamical Modeling and Multi-Experiment Fitting with PottersWheel
T. Maiwald and J. Timmer
Bioinformatics 2008, 24(18):2037-2043

Extensions to PottersWheel exist to detect and characterize parameter non-identifiabilities based on the Diploma Theses from Dipl. Phys. Stefan Hengl (now at ETH Zürich) and Dipl. Phys. Andreas Raue (Freiburg University):

Data-based identifiability analysis of nonlinear dynamical models
S. Hengl, C. Kreutz, J. Timmer, T Maiwald
Bioinformatics 2007, 23, 2612-2618

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood
A. Raue, C. Kreutz, T. Maiwald, J. Bachmann, M. Schilling, U. Klingmüller, J. Timmer
Bioinformatics 2009, 25(15):1923-1929

The ongoing development by the PottersWheel team is funded by the TIKANIS GmbH, a company for scientific and clinical software development located in Freiburg, Germany. Additional funding has been provided in 2008 by the EXIST grant from the German Federal Ministry of Economics and Technology and in 2009/2010 by the Young Innovators initiative from the Baden-Württemberg Ministry of Science, Research and the Arts, Germany.

 

Awards

MTZ-Foundation Award 2010 for young scientists that outstandingly contribute to the research in Medical Systems Biology.

Reinhart-Heinrich Thesis Award 2008 for the thesis "Dynamical Modeling of Biological Systems" of Thomas Maiwald.